Figure 2.

Ulcerated lesions in the hand and fist of a patient with human immunodeficiency virus (HIV) infection ad cutaneous disseminated sporotrichosis and immune reconstitution syndrome (A). A skin biopsy (B) depicted an exudative and granulomatous infiltrate with cigar shape and round yeast cells (arrow head), imbibed in multinucleate giant cells of the Langerhans type. Periodic Acid-Schiff stain × 400. The patient responded well to long course of continuous itraconazole intercalated with short courses of cotrimoxazole for secondary bacterial infection and prednisone for immune reconstitution inflammatory syndrome (IRIS) control (C).