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. 2018 Dec 22;6(1):2. doi: 10.3390/jcdd6010002

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cardiac regeneration enhancer elements. (A) Cardiomyocyte (CM)-specific enhancers in zebrafish. CM-specific histone H3.3 profiling of uninjured and regenerating zebrafish hearts captures regulatory elements preferential for heart development and regeneration. (B) ChIP-seq analysis with active enhancer markers, such as H3K27ac, identifies lepb-linked regeneration enhancer (LEN), which can direct regeneration-specific expression in hearts and fins of zebrafish. (C) LEN consists of tissue-specific regeneration modules, each of which mediates gene transcription in their target tissues.