Table 3.
Interaction between daily dietary intake and TCF7L2 (rs7903146) genotypes with BMI (kg/m2).
| No. of Subjects by Genotype (CC/CT/TT) | CC Mean (95% CI) (N = 134) | CT Mean (95% CI) (N = 130) | TT Mean (95% CI) (N = 43) | p-Trend 1 | p-Trend 2 | p-Trend 3 | p-Interaction 1 | p-Interaction 2 | p-Interaction 3 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Among ALL | 134/130/43 | 27.57 (26.61–28.54) | 27.79 (26.84–28.73) | 28.37 (26.46–30.28) | 0.42 | 0.47 | 0.48 | - | - | - |
| Carbohydrates (% of energy) | ||||||||||
| Tertile 1 (<47.317) | 43/46/15 | 28.96 (27.29–30.63) | 27.95 (26.44–29.46) | 26.69 (23.18–30.20) | 0.17 | 0.20 | 0.20 | 0.10 | 0.11 | 0.17 |
| Tertile 2 (47.317–53.984) | 44/49/15 | 26.07 (24.24–27.89) | 27.62 (26.13–29.10) | 28.74 (26.11–31.38) | 0.11 | 0.15 | 0.12 | |||
| Tertile 3 (>53.984) | 47/35/13 | 27.71 (26.16–29.27) | 27.82 (25.64–30.00) | 29.87 (25.39–34.36) | 0.25 | 0.30 | 0.33 | |||
| Fat (% of energy) | ||||||||||
| Tertile 1 (<35.131) | 47/28/16 | 27.69 (25.80–29.58) | 28.58 (25.80–31.35) | 27.53 (25.10–29.96) | 0.93 | 0.87 | 0.87 | 0.24 | 0.35 | 0.33 |
| Tertile 2 (35.131–41.333) | 46/51/14 | 26.10 (24.85–27.35) | 27.72 (26.45–29.00) | 31.03 (26.64–35.42) | 0.001 | 0.003 | 0.002 | |||
| Tertile 3 (>41.333) | 41/51/13 | 29.09 (27.26–30.93) | 27.42 (25.94–28.90) | 26.53 (23.06–30.01) | 0.15 | 0.21 | 0.19 | |||
| Protein (% of energy) | ||||||||||
| Tertile 1 (<11.700) | 53/50/18 | 28.01 (26.53–29.49) | 27.64 (26.26–29.02) | 27.81 (25.26–30.35) | 0.88 | 0.92 | 0.86 | 0.54 | 0.61 | 0.56 |
| Tertile 2 (11.700–13.985) | 45/36/14 | 26.54 (24.87–28.21) | 26.76 (25.17–28.36) | 28.70 (24.48–32.93) | 0.21 | 0.31 | 0.30 | |||
| Tertile 3 (>13.985) | 36/44/11 | 28.21 (26.14–30.28) | 28.80 (26.83–30.77) | 28.86 (24.30–33.43) | 0.77 | 0.66 | 0.63 | |||
| Saturated fat (% of energy) | ||||||||||
| Tertile 1 (<8.595) | 40/33/11 | 27.36 (25.63–29.09) | 27.87 (25.90–29.85) | 30.86 (25.74–35.99) | 0.08 | 0.08 | 0.09 | 0.020 | 0.015 | 0.016 |
| Tertile 2 (8.595–11.034) | 47/42/15 | 26.62 (24.92–28.32) | 28.64 (26.76–30.51) | 28.44 (25.16–31.73) | 0.30 | 0.17 | 0.16 | |||
| Tertile 3 (>11.034) | 47/55/17 | 28.71 (27.05–30.36) | 27.09 (25.77–28.41) | 26.69 (24.05–29.33) | 0.18 | 0.16 | 0.16 | |||
| MUFA (% of energy) | ||||||||||
| Tertile 1 (<11.890) | 43/37/12 | 27.70 (26.04–29.37) | 28.17 (25.93–30.40) | 27.58 (24.50–30.66) | 0.95 | 0.99 | 0.91 | 0.82 | 0.94 | 0.99 |
| Tertile 2 (11.890–14.571) | 54/39/16 | 27.26 (25.64–28.88) | 27.53 (26.13–28.93) | 29.72 (26.56–32.89) | 0.11 | 0.22 | 0.12 | |||
| Tertile 3 (>14.571) | 37/54/15 | 27.88 (25.98–29.77) | 27.72 (26.27–29.16) | 27.55 (23.42–31.69) | 0.85 | 0.95 | 0.99 | |||
| PUFA (% of energy) | ||||||||||
| Tertile 1 (<8.426) | 49/41/18 | 27.84 (25.94–29.74) | 28.10 (26.08–30.11) | 27.49 (23.97–31.00) | 0.85 | 0.89 | 0.82 | 0.79 | 0.68 | 0.72 |
| Tertile 2 (8.426–10.930) | 49/43/15 | 26.38 (25.12–27.64) | 28.06 (26.46–29.66) | 29.42 (26.74–32.11) | 0.033 | 0.037 | 0.034 | |||
| Tertile 3 (>10.930) | 36/46/10 | 28.83 (26.93–30.74) | 27.26 (25.83–28.69) | 28.37 (23.58–33.17) | 0.81 | 0.69 | 0.69 |
1 p-value crude; 2 p-value adjusted for age and sex; 3 p-value adjusted for age, sex, and physical activity; p-values that are statistically significant are in bold.