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. 2019 Mar 13;8(3):355. doi: 10.3390/jcm8030355

Figure 7.

Figure 7

Correlation of combined GLS and GLS2 gene expression with various cancer prognoses (PROGgeneV2 and Kaplan-Meier Plotter databases). (a) Survival curve comparing patients with high (red) and low (green) expression of combined GLS and GLS2, plotted using the PROGgeneV2 database in breast (i), brain (ii), colon (iii), lung (iv), ovarian (v), pancreatic (vi), kidney (vii), gastric (viii), and thymoma (ix) cancer; the cohort was divided according to the median of gene expression, with a threshold of Cox p-value < 0.05. (b) Survival curve comparing patients with high/high (red), high/low (orange), low/high (green), and low/low (blue) expression of combined GLS and GLS2, plotted using the data retrieved from Kaplan-Meier Plotter database for breast (i), ovarian (ii), lung (iii), and gastric (iv) cancer; with a threshold of Cox p-value < 0.05. (c) Survival curve comparing patients with high (red) and low (green) expression of combined GLS with 10 interacted genes from PPI data plotted using the SurvExpress database in BRCA (i), COAD (ii), LIHC (iii), HNSC (iv) cancer; the cohort was divided according to the median of gene expression, with a threshold of Cox p-value < 0.05. (d) Survival curve comparing patients with high (red) and low (green) expression of combined GLS2 with 10 interacted genes from PPI data plotted using the SurvExpress database in COAD (i), HNSC (ii), LUAD (iii), LAML (iv) cancer; the cohort was divided according to the median of gene expression, with a threshold of Cox p-value < 0.05. (Abbreviations: BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; HNSC, head-and-neck squamous cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LAML, Acute Myeloid Leukemia).