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. 2019 Jan 22;6(1):6. doi: 10.3390/jcdd6010006

Figure 1.

Figure 1

Illustrations of significant stages of zebrafish heart development. At 1 dpf the heart begins pumping as a valveless heart tube, at 1.5 dpf cardiac looping and chamber ballooning begins, at 2 dpf the heart is a growing two-chambered pumping system with endocardial cushions forming, and at 3 dpf ventricular trabeculation occurs. The blue arrows indicate blood flow while the black dotted arrows represent mechanical stresses re-configuring the heart.