Table 2.
Results of carriers’ survey on knowledge and concerns on Risk-Reducing Surgery and screening procedures, considering their medical history (healthy one versus those who had a previous Breast or Ovarian Cancer).
| Questions | Results as a Median (Range) [% Reporting a Score of ≥8/10] | |||
|---|---|---|---|---|
| Overall (204 pts) |
Healthy (104 pts) |
Previous BC or OC (100 pts) |
p-Value * | |
| On a scale of 1 (incompetent) to 10 (very competent), how do you estimate your knowledge on…? | ||||
| RR Mastectomy | 9 (1–10) [80.1%] | 9 (4–10) [78.8%] | 9 (1–10) [83.0%] | NS |
| Clinical and instrumental screening for BC | 9 (2–10) [83.3%] | 9 (6–10) [88.4%] | 9 (2–10) [78.0%] | 0.0413 |
| RR Salpingo-Oophorectomy | 9 (1–10) [79.9%] | 9 (5–10) [80.7%] | 9 (1–10) [79.0%] | NS |
| Clinical and instrumental screening for OC | 9 (1–10) [75.9%] | 9 (3–10) [82.6%] | 8 (1–10) [69.0%] | 0.0042 |
| Healthy lifestyle in reducing BC and OC | 8 (1–10) [59.8%] | 8 (1–10) [59.6%] | 8 (1–10) [60.0%] | NS |
| On a scale of 1 (little) to 10 (very), how much are you afraid of…? | ||||
| Possible development of BC and OC | 8 (1–10) [62.3%] | 8 (1–10) [61.5%] | 9 (1–10) [63.0%] | NS |
| Failure of clinical and instrumental screening | 7 (1–10) [42.6%] | 5 (1–10) [36.5%] | 7 (1–10) [49.0%] | 0.0102 |
| RRSO related menopausal symptoms | 7 (1–10) [45.1%] | 7 (1–10) [49.0%] | 7 (1–10) [41.0%] | NS |
| RRM related poor cosmetic results | 6 (1–10) [35.3%] | 7 (1–10) [39.4%] | 6 (1–10) [31.0%] | NS |
| Which were your sources of information on Risk-Reducing Surgery? | ||||
| Genetic counselling | 58.3% (119 pts) | 61.5% (64 pts) | 55.0% (55 pts) | NS° |
| Gynaecological consultation | 24.5% (50 pts) | 19.2% (20 pts) | 30.0% (30 pts) | NS° |
| Websites, patients’ forums, patients’ society and journals | 10.7% (22 pts) | 10.6% (11 pts) | 11.0% (11 pts) | NS° |
| Family and friends | 6.4% (13 pts) | 8.7% (9 pts) | 4.0% (4 pts) | NS° |
pts = participants, RRM = Risk-Reducing Mastectomy, RRSO = Risk-Reducing Salpingo-Oophorectomy; BC = Breast Cancer, OC = Ovarian Cancer, NS = not statistically significant. * p-value calculated with two-tailed Mann—Whitney U test. ° p-value calculated with Fisher Exact test.