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Competition between siRNAs’ Shifted siRNA Potency EC50
(A–C) Dose-response curves for (A) ApoB(19) with or without a competitor siRNA (SSB(291), (B) Apoa4(810) with or without a competitor siRNA Serpina6(1011), and (C) Apoa4(548) with or without a competitor siRNA Serpina6(1011) were measured in Hepa 1-6 cells for ApoB(19) or in primary mouse hepatocytes for Apoa4(810) and Apoa4(548). Data were fit to a sigmoidal dose-response curve; error bars, ±SD, n = 2.
