Figure 8.

Parametric Sensitivity Analysis Showing the Influence of Model Parameters on Ago2 Depletion

Sensitivity analysis carried out for all the model parameters, using the Simbiology toolbox in MATLAB. The bar graphs show the consolidated sensitivity metrics of Z (Ago2 depletion) with respect to model parameters. Parameters ranked from highest to lowest impact are as follows: endosomal escape (b), cell entry (a), siRNA-Ago2 loading (d), and degradation of siRNA in the cytoplasm (e). The other parameters did not seem to have an effect on Ago2 loading.