Figure 2. Loss of Cideb protects mice from diet‐induced fatty liver diseases.

• A
  Liver morphology of WT and Cideb ^−/− liver under chow diet and HFLF diet. H/E staining, oil red‐O staining, immunohistochemistry, and ultrastructure (Electron Microscope) were performed. Scale bar represented 50 μm in the upper three rows of images and 2 μm in the bottom row of images. LD: lipid droplet; ER: endoplasmic reticulum; M: mitochondrial; N: nucleus.
• B, C
  Total liver TAG levels (B) and liver cholesterol ester levels (C) of WT and Cideb ^−/− mice under chow diet and HFLF diet (n = 8 per group).
• D
  Loss of Cideb inhibits diet‐induced SREBP activation. IB of hepatic SREBP processing and lipogenic enzyme levels (Fasn, Scd1) of WT and Cideb ^−/− mice under chow diet and HFLF diet.
• E
  Serum AST and ALT levels of WT and Cideb ^−/− mice under chow diet and HFLF diet (n = 8 per group).
• F
  Cideb deficiency alleviates the whole body inflammation response. Serum TNFα, MCP1, and IL6 levels of WT and Cideb ^−/− mice under chow diet and HFLF diet (n = 8 per group).
• G, H
  Serum fed glucose levels (G) and insulin levels (H) of WT and Cideb ^−/− mice under chow diet and HFLF diet (n = 8 per group).
• I
  Glucose tolerance test (GTT) of WT and Cideb ^−/− mice under HFLF diet (n = 5 per group).
• J
  Insulin tolerance test (ITT) of WT and Cideb ^−/− mice under HFLF diet (n = 5 per group).

Data information: Data represent Mean ± SEM; NS: not significant; *P < 0.05; **P < 0.01; ***P < 0.001, by 2‐tailed Student's t‐test.Source data are available online for this figure.