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Conceptual model for primary analysis (total effect) and secondary analysis (mediated effect)
| Analysis | Covariates (V) | Exposure (A) | Mediator (M) | Outcome (Y) |
|---|---|---|---|---|
| Primary analysis (total effect) | Age Race Parity Body mass index |
Antenatal depression | Oxidative stress biomarkers, specific gravity adjusted: 8-isoprostane 8-OHdG Inflammatory biomarkers: IL-6 IL-10 IL-1β TNF-α CRP |
|
| Secondary analysis (mediated effect) | Age Race Parity Body mass index |
Antenatal depression | 8-isoprostane | SPTB |
