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LINC01419 is localized in the nucleus and its overexpression enhances the ability of GSTP1 to recruit methyltransferase DNMT1, DNMT3A and DNMT3B. The overexpression of LINC01419 promotes methylation of the promoter region of the GSTP1 gene, as well as acting to promote ESCC cell growth and reduce the sensitivity of ESCC cells to 5-FU.
5-FU, 5-fluorouracil; ESCC, esophageal squamous cell carcinoma; GSTP1, glutathione S-transferase pi 1.
