Figure 2.

Delayed GDNF treatment reversed SNL-induced reduction of I_A of injured large DRG neurons. (a) Comparison of representative waveforms of the depolarization-activated potassium currents of the ipsilateral (left) L5 DRG neurons obtained from the indicated groups. Total potassium currents and I_K were initiated via a prepulse of –120 mV (i) and –40 mV (ii) protocol, respectively, followed by a series test pulses rising from –60 mV to +60 mV in 10-mV steps. Subtraction total – I_K reveals I_A. (b) I–V relationships of I_A obtained from each group. (c) Comparison of current densities obtained from each group. Values represent mean ± SEM (n = 7). n.s. P > 0.05, ^#P < 0.05, ^###P < 0.001 by one-way ANOVA followed by Bonferroni’s multiple comparison tests. DRG: dorsal root ganglion; GDNF: glial cell line-derived neurotrophic factor; I_A: fast-inactivating transient A-current; I_K: slow-inactivating sustained K-current; n.s.: not significant; SNL: spinal nerve ligation.