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. 2019 Jan 21;10(2):378–390. doi: 10.1002/jcsm.12377

Figure 4.

Figure 4

MyD88 signalling is essential for muscle catabolism in pancreatic ductal adenocarcinoma cachexia. Mice were euthanized on Days 11–12 post‐implantation. (A) Gastrocnemius weight (average of left and right gastrocnemii). (B) Heart weight. Muscle weight was normalized to initial body weight and presented as loss (%) to sham mice of the same genotype. (C) Gene expression in gastrocnemius. (D) Gene expression in heart. *, P < 0.05; **, P < 0.01; ***, P < 0.001; WT/KPC vs. MyD88KO/KPC (A, B) or sham vs. KPC (C, D). Two‐way analysis of variance with post hoc Bonferroni‐corrected t‐test. N = 5/group.