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. 2019 Jan 21;10(2):378–390. doi: 10.1002/jcsm.12377

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© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Blockade of MyD88 signalling prevents muscle atrophy in pancreatic ductal adenocarcinoma cachexia. Mice were euthanized on Days 11–12 post‐implantation. (A) Immunohistochemistry (IHC): gastrocnemius cross sections immunostained with antibody against laminin (green). Blue is DAPI for nuclear counterstain. (B) Fibre cross‐sectional area (CSA). (C) Fibre CSA distribution. **, P < 0.01; WT/sham vs. WT/KPC. Two‐way analysis of variance with post hoc Bonferroni‐corrected t‐test. N = 4–5/group. Scale bars: 100 μm.