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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Nov 5;124:34–49. doi: 10.1016/j.addr.2017.11.001

Table 2:

Characteristics of different mucin KO models.

KO Model Similarities Between Muc KO and Wild Type Characteristics Increased in Muc KO Characteristics Decreased in Muc KO
Muc1
  • Viability and fertility[178]

  • Muc2 and Muc4 gene expression[178]

  • Gallbladder size, secretion, and emptying function[179]

  • Bacterial adherence to epithelium after Helicobacter pylori infection[180]

  • Wound healing rate[182, 183]

  • Pro-inflammatory response[176, 184186]

  • Tumor growth rate[177, 178]

  • Gallstone formation[179]

  • Drug resistance (e.g., gemcitabine, etoposide)[188]

  • Absorption of cholesterol[187]

Muc2
  • Weight gain[190]

  • Damage in intestinal injury model (e.g., dextran sulfate sodium (DSS))[191]

  • Onset of colorectal cancer[190]

  • Susceptibility to infection[189]

  • Mortality rate[189]

  • Weight loss, mortality, and colonization after Citrobacter rodentium infection[194]

  • Mucosal thickening and superficial erosions[191]

  • Aberrant intestinal crypt morphology, altered cell maturation and migration[190]

  • Pro-inflammatory response [191, 192]

  • Ratio of proliferating to apoptotic cells[190, 191]

  • Onset of fatty liver disease and obesity with a high fat diet[192]

  • Epithelial barrier integrity after Salmonella Typhimurium infection[189]

Muc5
  • External ocular appearance[195, 196]

  • Muc1 and Muc4 gene expression[195, 196]

  • Goblet cell number[196]

  • Number of CD45+ immune cells[196]

  • Susceptibility to Trichuris Muris infection[193]

  • Late onset respiratory problems[195]

  • Expression of Muc5b and Muc4[195197]

  • Corneal opacification[197]

  • Clearance of Trichuris Muris[193]

  • Tear quality[197]

  • Body weight[195]

  • Goblet cell number[195]

Muc13
  • Viability, fertility, development[198]

  • Onset of acute colitis, macrophage number, and apoptosis in intestinal injury models (e.g., DSS)[198]

  • Tumor necrosis factor (TNF-α) and Interleukin (IL)-1β expression[198]

  • IL-8 expression after Campylobacter jejuni infection[185]

Muc16
  • Viability, fertility, and development [199]

  • IL-6 expression [201]

  • Rate of wound healing[201]

  • Macrophage invasion[201]

  • Tumor formation and metastasis[200]

  • Pancreatic ductal adenocarcinoma cell proliferation, colony formation and migration in vitro[200]

  • Mucl expression[199]

Muc18
  • Pro-inflammatory cytokine (KC and TNF-α) expression after Mycoplasma pneumoniae infection[204]

  • Neutrophillic inflammation and viral load after humanrhino virus 1B (HRV-1B) infection[203]

  • IL-8 expression[202]

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