Skip to main content
. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Cell Rep. 2018 Dec 11;25(11):2955–2962.e3. doi: 10.1016/j.celrep.2018.11.060

Figure 4. Comparison between DUX4 and HoxB1-Pbx1 Heterodimer.

Figure 4.

(A and B) A side-by-side comparison between DUX4 (A) and HoxB1-Pbx1 heterodimer (B) (LaRonde-LeBlanc and Wolberger, 2003; Piper et al., 1999) bound to respective DNA substrate, highlighting similarity in the positioning of a key Trp residue in coordinating the two homeodomains. (C and D) Close-up views of DUX4 (C) and HoxB1-Pbx1 heterodimer (D) bound to respective DNA substrate (as in A and B) highlighting distinct local interactions surrounding the key Trp residue docked in a hydrophobic pocket.