Table 3.

Increased risk of cardiovascular events and mortality associated with severe hypoglycemia within the prior 3 months

	All participants*		Standard treatment group only	Intensive treatment group only
	HR (95% CI)	P value	HR (95% CI)	HR (95% CI)	P value for interaction effect by treatment group
Cardiovascular event	1.9 (1.06, 3.52)	0.032	2.50 (1.0, 6.1)	1.7 (0.75, 3.83)	>0.2
Cardiovascular mortality	3.7 (1.3, 10.4)	0.012	8.6 (1.9, 37.7)	2.1 (0.51, 8.9)	0.184
All-cause mortality	2.4 (1.1, 5.1)	0.024	6.7 (2.7, 16.6)	0.92 (0.23, 3.8)	0.019

*Adjusted for treatment group, cardiovascular risk (as estimated by UKPDS score), history of cardiovascular event, insulin at baseline, and eGFR.