Table 13.
Summary of gross necropsy findings, males and females.
| Organs | Group and Dose (mg/kg b.w.) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diagnoses |
G1 | G1R | G2 | G3 | G4 | G4R | ||||||
| 0 | 0 | 150 | 300 | 600 | 600 | |||||||
| TS | TS | TS | TS | TS | TS | |||||||
| M | F | M | F | M | F | M | F | M | F | M | F | |
| [10] | [10] | [5] | [5] | [10] | [10] | [10] | [10] | [10] | [10] | [5] | [5] | |
| Liver | ||||||||||||
| No Abnormality Detected | 10 | 10 | 5 | 5 | 10 | 10 | 10 | 10 | 10 | 8 | 5 | 5 |
| Small white to yellow irregular area, focal | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
|
| ||||||||||||
| Lungs | ||||||||||||
| No Abnormality Detected | 10 | 10 | 5 | 5 | 10 | 10 | 10 | 10 | 8 | 7 | 5 | 4 |
| Small yellow foci | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 1 |
Note: the numerical indicated under observation represents the number of animals with and without lesions; M: male; F: female; TS: terminal sacrifice.