Table 1.

SOX9 expression and functions in human cancers.

Type of cancer	Status of SOX9	Sox9 participation	References
Hepatocellular carcinoma	overexpression	Related whit poor prognosis Related with poor disease free survival Related with poor overall survival	[22, 23]
Breast cancer	overexpression	Promotes proliferation, tumorigenesis and metastasis Related with poor overall survival	[24]
Bladder cancer	overexpression	Promotes tumorigenesis Related with poor overall survival	[25]
Gastric cancer	overexpression	Promotes chemoresistance Related with poor disease free survival	[26]
Prostate cancer	overexpression	Promotes cell proliferation and apoptosis resistance Related with high clinical stage Related with poor relapse free survival Related with poor overall survival	[27]
Prostate cancer	downregulation	Promotes metastasis Related with advanced clinical stage Related with EGR-positive tumors	[28]
Ovarian cancer	overexpression	Its coexpression with HIF-2α induces the expression of TUBB3 which is related with poor overall survival	[29]
Pancreatic cancer	overexpression	Promotes chemoresistance	[30]
colorectal cancer	overexpression	Promotes cell proliferation, senescence inhibition and chemoresistance	[31–33]