Table 2.
Results of non-linear fitting of viral dynamics
| Patient (1) | Initial viral load (log copies/ml) | % blocking production | Half-life(2) of free virions (hours) | Half-life of infected cells (days) | |
| During 10 MU qd | After reduction to 3 MU qd | minimal and maximal estimates (3) | |||
| 1-A | 6.9 | 98.4 | 2.3 | 8.7–8.8 | |
| 1-B | 6.9 | 99.9 | 2.5 | 3.0–3.0 | |
| 1-C | 6.7 | 99.5 | 2.2 | 1.7–1.7 | |
| 1-D | 6.1 | 86.9 | 1.9 | 7.8–9.0 | |
| 1-E | 5.8 | 99.5 | 5.3 | 4.4–4.5 | |
| 1-F | 6.4 | 98.5 | 6.4 | 3.2–3.2 | |
| 1-G | 7.0 | 95.1 | 1.8 | 6.1–6.4 | |
| 1-H | 7.1 | 99.8 | 1.7 | 1.1–1.1 | |
| 1-I | 7.4 | 98.9 | 3.3 | 4.9–4.9 | |
| Group 1(4) mean (std) | 6.7 (0.5) | 97.4 % (0.04) | 3.0 hours (1.7) | 4.5–4.7 days (2.6–2.8) | |
| 2-A | 7.3 | 93.0 | 62.5 | 1.8 | 4.8–7.7 |
| 2-C | 6.8 | 98.1 | 78.5 | 3.3 | 0.9–1.2 |
| 2-E | 6.7 | 93.8 | 86.0 | 3.3 | 7.1–8.2 |
| 2-F | 6.5 | 99.6 | 95.2 | 1.9 | 1.0–1.0 |
| 2-G | 7.2 | 97.8 | 85.0 | 3.3 | 4.0–4.7 |
| 2-H | 7.3 | 95.5 | 27.8 | 3.9 | 1.2–4.7 |
| 2-I | 6.1 | 98.1 | 88.0 | 1.1 | 11.8–13.5 |
| 2-J | 7.1 | 99.9 | 98.0 | 1.6 | 3.4–3.4 |
| 2-K | 7.1 | 71.4 | 25.2 | 2.1 | 2.6–2.7 |
| 2-L | 6.3 | 99.6 | 99.6 | 6.9 | 2.2–2.3 |
| 2-M | 7.4 | 93.0 | 81.1 | 2.1 | 12.0–14.8 |
| 2-N | 6.8 | 92.4 | 33.2 | 3.6 | 2.5–7.7 |
| Group 2(4) mean (std) | 6.9 (0.4) | 94.3% (0.08) | 69.1% (**) (26.6) | 2.9 hours (1.6) | 4.4–6.7 days (3.9–4.6) |
1) Fitting was not done for: patients 2-B (non-detectable at day 2 on), 2-D (Null-response), 2-O (missing data and rebound). 2) For group 1 half-life of free virions is only a maximal estimate because only samples from 0, 8 and 24 hours were available. 3) Minimal and maximal estimates of the half-life of infected cells was estimated assuming Η = 1 and Η = 0 respectively in Eq 2. 4) No statistically significant differences in any parameter between the two groups. **) Statistically significant (p < 0.002) difference in percentage blocking production before and after dose reduction in group 2.