Table 2.
Rates and rate ratios with 95% CI of an event (CVD or mortality) for prediabetes subgroups, using the WHO/IEC criteria or the ADA criteria
| Definition | Rate per 1,000 PY | RR | RRadj1 | RRadj2 | |
|---|---|---|---|---|---|
| WHO/IEC | |||||
| Overall | |||||
| Normal glycemia | FPG <6.1 mmol/L and HbA1c <6.0% | 14.8 (13.7; 15.9) | ref. | ref. | ref. |
| Prediabetes | FPG 6.1–6.9 mmol/L or HbA1c 6.0–6.4% | 22.7 (19.2; 26.9) | 1.54 (1.28; 1.85) | 1.51 (1.25; 1.81) | 1.17 (0.97; 1.41) |
| By HbA1c | |||||
| Normal glycemia | HbA1c <6.0% | 14.9 (13.9; 15.9) | ref. | ref. | ref. |
| Prediabetes | HbA1c 6.0–6.4% | 29.5 (23.4; 37.3) | 1.99 (1.55; 2.53) | 1.52 (1.19; 1.95) | 1.13 (0.88; 1.46) |
| By FPG | |||||
| Normal glycemia | FPG <6.1 mmol/L | 15.3 (14.2; 16.4) | ref. | ref. | ref. |
| Prediabetes | FPG 6.1–6.9 mmol/L | 19.4 (15.6; 24.2) | 1.27 (1.01; 1.60) | 1.17 (0.93; 1.48) | 1.00 (0.79; 1.26) |
| By 2hPG | |||||
| Normal glycemia | 2hPG <7.8 mmol/L | 13.4 (12.4; 14.6) | ref. | ref. | ref. |
| Prediabetes | 2hPG 7.8–11.0 mmol/L | 19.3 (16.3; 23.0) | 1.44 (1.19; 1.75) | 1.14 (0.94; 1.39) | 1.00 (0.82; 1.22) |
| ADA | |||||
| Overall | |||||
| Normal glycemia | FPG <5.6 mmol/L and HbA1c <5.7% | 13.8 (12.7; 15.1) | ref. | ref. | ref. |
| Prediabetes | FPG 5.6–6.9 mmol/L or HbA1c 5.7–6.4% | 18.9 (17.1; 21.0) | 1.37 (1.20; 1.57) | 1.34 (1.17; 1.54) | 1.12 (0.97; 1.28) |
| By HbA1c | |||||
| Normal glycemia | HbA1c <5.7% | 13.7 (12.7; 14.8) | ref. | ref. | ref. |
| Prediabetes | HbA1c 5.7–6.4% | 26.0 (22.6; 29.8) | 1.89 (1.62; 2.22) | 1.49 (1.27; 1.75) | 1.17 (1.00; 1.38) |
| HbA1c 5.7–5.9% | 24.6 (20.8; 29.0) | 1.79 (1.50; 2.15) | 1.43 (1.19; 1.72) | 1.18 (0.98; 1.42) | |
| HbA1c 6.0–6.4% | 29.5 (23.4; 37.3) | 2.15 (1.68; 2.76) | 1.62 (1.26; 2.08) | 1.13 (0.87; 1.46) | |
| By FPG | |||||
| Normal glycemia | FPG <5.6 mmol/L | 15.2 (14.1; 16.5) | ref. | ref. | ref. |
| Prediabetes | FPG 5.6–6.9 mmol/L | 16.5 (14.5; 18.7) | 1.08 (0.93; 1.25) | 1.00 (0.86; 1.16) | 0.93 (0.80; 1.08) |
| FPG 5.6–6.0 mmol/L | 15.4 (13.2; 17.9) | 1.01 (0.85; 1.20) | 0.94 (0.79; 1.12) | 0.91 (0.76; 1.08) | |
| FPG 6.1–6.9 mmol/L | 19.4 (15.6; 24.2) | 1.27 (1.01; 1.61) | 1.16 (0.91; 1.46) | 0.98 (0.77; 1.24) | |
| By 2hPG | |||||
| Normal glycemia | 2hPG <7.8 mmol/L | 13.4 (12.4; 14.6) | ref. | ref. | ref. |
| Prediabetes | 2hPG 7.8–11.0 mmol/L | 19.3 (16.3; 23.0) | 1.44 (1.19; 1.75) | 1.14 (0.94; 1.39) | 1.00 (0.82; 1.22) |
ref., reference; RR, crude rate ratio; RRadj1, rate ratio adjusted for age, sex, and ethnicity; RRadj2, rate ratio adjusted for age, sex, ethnicity, previous CVD, smoking, total cholesterol, HDL cholesterol, systolic blood pressure, and antihypertensive treatment.