Table 2.
Patient characteristics according to steatosis grades based on MR proton density fat fraction
| Steatosis grades | |||||
|---|---|---|---|---|---|
| S0 (n = 10) | S1 (n = 25) | S2 (n = 14) | S3 (n = 37) | p-value* | |
| Age (y) | 13 (9–17) | 14 (7–18) | 13 (10–18) | 12 (9–18) | 0.209 |
| Female (n, %) | 5 (50.0) | 8 (32.0) | 5 (35.7) | 6 (16.2) | 0.134† |
| BMI (kg/m2) | 20.6 (14.7–25.9) | 26.3 (18.0–38.5) | 26.5 (19.2–30.9) | 28.3 (19.3–40.6) | 0.002 |
| AWT (cm) | 1.7 (1–2.9) | 2.7 (1.3–4.3) | 2.5 (1.8–3.2) | 2.8 (1.8–4.7) | 0.003 |
| AST (U/L) | 21.5 (17–26) | 52 (12–241) | 36 (17–197) | 63 (25–179) | < 0.001 |
| ALT (U/L) | 15 (8–28) | 95 (8–430) | 61 (22–234) | 96 (23–346) | < 0.001 |
| Total bilirubin (mg/dL) | 0.6 (0.3–0.8) | 0.6 (0.3–1.2) | 0.5 (0.3–1.6) | 0.5 (0.3–0.9) | 0.089 |
| Albumin (g/dL) | 4.4 (4.2–5.1) | 4.6 (3.7–5.2) | 4.5 (4.0–4.9) | 4.6 (4.3–5.1) | 0.249 |
| ALP (IU/L) | 217 (69–325) | 152 (38–405) | 201 (59–308) | 242 (65–466) | 0.032 |
| Cholesterol (mg/dL) | 161.5 (127–231) | 184 (144–306) | 205 (151–222) | 191 (125–276) | 0.044 |
| TG (mg/dL) | 91 (44–419) | 117 (58–240) | 144.5 (55–322) | 158 (54–487) | 0.045 |
| HDL (mg/dL) | 50.5 (26–66) | 39 (26–70) | 44 (28–50) | 47 (30–65) | 0.133 |
| LDL (mg/dL) | 79.1 (60.2–106.8) | 117.6 (71.2–235.8) | 128 (90.8–183) | 107.8 (66.6–205) | 0.010 |
| PDFF (%) | 3.5 (2.6–5.2) | 13.9 (6.8–17) | 19.5 (17.8–23.1) | 33.7 (24–48) | < 0.001 |
| CAP (dB/m) | 222.5 (157–311) | 308 (216–400) | 301 (271–384) | 329 (272–399) | < 0.001 |
The values are median (range) or number (percentage)
*Non-parametric method, Kruskal-Wallis test, was performed to compare groups, unless otherwise indicated
†Chi-square test was performed to compare groups. All the p-values of boldface are less than 0.05
Notes: AWT abdominal wall thickness, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, TG triglycerides, HDL high-density lipoprotein, LDL low-density lipoprotein, PDFF proton density fat fraction, CAP controlled attenuation parameter