Table 1.
Functional enrichment analysis of upregulated genes in the old mouse ovarian secondary follicles compared to young mouse.
| Category | Term | Count∗ | % | P Value |
|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0035458~cellular response to interferon-beta | 15 | 8.6 | 5.62E-21 |
| GOTERM_BP_DIRECT | GO:0009615~response to virus | 18 | 10.3 | 6.73E-21 |
| GOTERM_BP_DIRECT | GO:0051607~defense response to virus | 21 | 12.1 | 1.15E-19 |
| GOTERM_BP_DIRECT | GO:0002376~immune system process | 24 | 13.8 | 1.01E-15 |
| GOTERM_BP_DIRECT | GO:0045087~innate immune response | 23 | 13.2 | 2.70E-14 |
| GOTERM_BP_DIRECT | GO:0071346~cellular response to interferon-gamma | 9 | 5.2 | 1.80E-08 |
| GOTERM_BP_DIRECT | GO:0042832~defense response to protozoan | 6 | 3.4 | 1.60E-06 |
| GOTERM_BP_DIRECT | GO:0006952~defense response | 8 | 4.6 | 1.36E-05 |
| GOTERM_BP_DIRECT | GO:0032870~cellular response to hormone stimulus | 6 | 3.4 | 1.57E-05 |
| GOTERM_BP_DIRECT | GO:0034097~response to cytokine | 7 | 4.0 | 1.79E-05 |
| GOTERM_CC_DIRECT | GO:0020005~symbiont-containing vacuole membrane | 5 | 2.9 | 1.46E-07 |
| GOTERM_CC_DIRECT | GO:0005829~cytosol | 28 | 16.1 | 7.00E-05 |
| GOTERM_CC_DIRECT | GO:0005737~cytoplasm | 65 | 37.4 | 6.61E-04 |
| GOTERM_CC_DIRECT | GO:0005634~nucleus | 58 | 33.3 | 2.75E-03 |
| GOTERM_CC_DIRECT | GO:0048471~perinuclear region of cytoplasm | 12 | 6.9 | 8.23E-03 |
| GOTERM_CC_DIRECT | GO:0072562~blood microparticle | 5 | 2.9 | 1.34E-02 |
| GOTERM_CC_DIRECT | GO:0031225~anchored component of membrane | 5 | 2.9 | 1.63E-02 |
| GOTERM_CC_DIRECT | GO:0009897~external side of plasma membrane | 7 | 4.0 | 2.23E-02 |
| GOTERM_MF_DIRECT | GO:0003725~double-stranded RNA binding | 9 | 5.2 | 2.62E-08 |
| GOTERM_MF_DIRECT | GO:0003690~double-stranded DNA binding | 11 | 6.3 | 3.33E-08 |
| GOTERM_MF_DIRECT | GO:0003924~GTPase activity | 11 | 6.3 | 1.81E-06 |
| GOTERM_MF_DIRECT | GO:0005525~GTP binding | 12 | 6.9 | 6.76E-05 |
| GOTERM_MF_DIRECT | GO:0008134~transcription factor binding | 10 | 5.7 | 5.97E-04 |
| GOTERM_MF_DIRECT | GO:0003723~RNA binding | 15 | 8.6 | 9.40E-04 |
| GOTERM_MF_DIRECT | GO:0003677~DNA binding | 25 | 14.4 | 1.58E-03 |
| GOTERM_MF_DIRECT | GO:0001730~2′-5′-oligoadenylate synthetase activity | 3 | 1.7 | 2.48E-03 |
| GOTERM_MF_DIRECT | GO:0016817~hydrolase activity, acting on acid anhydrides | 3 | 1.7 | 2.48E-03 |
| GOTERM_MF_DIRECT | GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 8 | 4.6 | 2.65E-03 |
∗Number of enriched genes in each term. The top ten terms based on P value were chosen in each category.