Table 2.
Functional enrichment analysis of downregulated genes in the old mouse ovarian secondary follicles compared to young mouse.
| Category | Term | Count∗ | % | P value |
|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0006355~regulation of transcription, DNA-templated | 42 | 21.3 | 7.02E-05 |
| GOTERM_BP_DIRECT | GO:0016311~dephosphorylation | 8 | 4.1 | 9.84E-05 |
| GOTERM_BP_DIRECT | GO:0006351~transcription, DNA-templated | 35 | 17.8 | 3.19E-04 |
| GOTERM_BP_DIRECT | GO:0045893~positive regulation of transcription, DNA-templated | 16 | 8.1 | 5.56E-04 |
| GOTERM_BP_DIRECT | GO:0030335~positive regulation of cell migration | 9 | 4.6 | 8.87E-04 |
| GOTERM_BP_DIRECT | GO:0006470~protein dephosphorylation | 7 | 3.6 | 2.39E-03 |
| GOTERM_BP_DIRECT | GO:0043154~negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5 | 2.5 | 4.21E-03 |
| GOTERM_BP_DIRECT | GO:0030177~positive regulation of Wnt signaling pathway | 4 | 2.0 | 5.61E-03 |
| GOTERM_BP_DIRECT | GO:0043065~positive regulation of apoptotic process | 10 | 5.1 | 5.85E-03 |
| GOTERM_BP_DIRECT | GO:0097194~execution phase of apoptosis | 3 | 1.5 | 6.92E-03 |
| GOTERM_CC_DIRECT | GO:0005634~nucleus | 106 | 53.8 | 3.23E-13 |
| GOTERM_CC_DIRECT | GO:0005737~cytoplasm | 100 | 50.8 | 4.49E-08 |
| GOTERM_CC_DIRECT | GO:0005654~nucleoplasm | 44 | 22.3 | 9.26E-08 |
| GOTERM_CC_DIRECT | GO:0070062~extracellular exosome | 50 | 25.4 | 3.19E-06 |
| GOTERM_CC_DIRECT | GO:0043234~protein complex | 19 | 9.6 | 3.26E-05 |
| GOTERM_CC_DIRECT | GO:0071013~catalytic step 2 spliceosome | 6 | 3.0 | 2.24E-03 |
| GOTERM_CC_DIRECT | GO:0005925~focal adhesion | 11 | 5.6 | 4.30E-03 |
| GOTERM_CC_DIRECT | GO:0005829~cytosol | 29 | 14.7 | 5.76E-03 |
| GOTERM_CC_DIRECT | GO:0030529~intracellular ribonucleoprotein complex | 9 | 4.6 | 1.17E-02 |
| GOTERM_CC_DIRECT | GO:0005911~cell-cell junction | 7 | 3.6 | 1.26E-02 |
| GOTERM_MF_DIRECT | GO:0005515~protein binding | 77 | 39.1 | 6.99E-09 |
| GOTERM_MF_DIRECT | GO:0044822~poly(A) RNA binding | 30 | 15.2 | 2.52E-06 |
| GOTERM_MF_DIRECT | GO:0003723~RNA binding | 20 | 10.2 | 3.71E-04 |
| GOTERM_MF_DIRECT | GO:0003677~DNA binding | 35 | 17.8 | 4.23E-04 |
| GOTERM_MF_DIRECT | GO:0004725~protein tyrosine phosphatase activity | 7 | 3.6 | 4.62E-04 |
| GOTERM_MF_DIRECT | GO:0046982~protein heterodimerization activity | 15 | 7.6 | 7.77E-04 |
| GOTERM_MF_DIRECT | GO:0000166~nucleotide binding | 35 | 17.8 | 9.78E-04 |
| GOTERM_MF_DIRECT | GO:0016791~phosphatase activity | 7 | 3.6 | 1.29E-03 |
| GOTERM_MF_DIRECT | GO:0019903~protein phosphatase binding | 6 | 3.0 | 2.02E-03 |
| GOTERM_MF_DIRECT | GO:0005524~ATP binding | 28 | 14.2 | 2.62E-03 |
∗Number of enriched genes in each term. The top ten terms based on P value were chosen in each category.