Table 3.
Pathway enrichment analysis of differentially expressed genes in old mouse ovarian secondary follicles compared to young mouse.
| Category | Term | Count∗ | % | P value |
|---|---|---|---|---|
| Up-regulated | ||||
| KEGG_PATHWAY | mmu05164:Influenza A | 15 | 8.6 | 2.25E-11 |
| KEGG_PATHWAY | mmu05168:Herpes simplex infection | 15 | 8.6 | 3.13E-10 |
| KEGG_PATHWAY | mmu05162:Measles | 11 | 6.3 | 6.23E-08 |
| KEGG_PATHWAY | mmu05160:Hepatitis C | 11 | 6.3 | 6.23E-08 |
| KEGG_PATHWAY | mmu04380:Osteoclast differentiation | 8 | 4.6 | 4.40E-05 |
| KEGG_PATHWAY | mmu05161:Hepatitis B | 8 | 4.6 | 1.12E-04 |
| KEGG_PATHWAY | mmu04622:RIG-I-like receptor signaling pathway | 6 | 3.4 | 1.58E-04 |
| KEGG_PATHWAY | mmu04668:TNF signaling pathway | 7 | 4.0 | 1.69E-04 |
| KEGG_PATHWAY | mmu04620:Toll-like receptor signaling pathway | 6 | 3.4 | 9.93E-04 |
| KEGG_PATHWAY | mmu05133:Pertussis | 5 | 2.9 | 2.38E-03 |
| Down-regulated | ||||
| KEGG_PATHWAY | mmu04151:PI3K-Akt signaling pathway | 14 | 7.1 | 4.14E-04 |
| KEGG_PATHWAY | mmu05200:Pathways in cancer | 14 | 7.1 | 1.31E-03 |
| KEGG_PATHWAY | mmu04550:Signaling pathways regulating pluripotency of stem cells | 8 | 4.1 | 1.69E-03 |
| KEGG_PATHWAY | mmu04520:Adherens junction | 6 | 3.0 | 2.03E-03 |
| KEGG_PATHWAY | mmu04015:Rap1 signaling pathway | 9 | 4.6 | 5.33E-03 |
| KEGG_PATHWAY | mmu04390:Hippo signaling pathway | 7 | 3.6 | 1.16E-02 |
| KEGG_PATHWAY | mmu05145:Toxoplasmosis | 6 | 3.0 | 1.36E-02 |
| KEGG_PATHWAY | mmu04510:Focal adhesion | 8 | 4.1 | 1.51E-02 |
| KEGG_PATHWAY | mmu04022:cGMP-PKG signaling pathway | 7 | 3.6 | 2.04E-02 |
| KEGG_PATHWAY | mmu03040:Spliceosome | 6 | 3.0 | 2.57E-02 |
∗Number of enriched genes in each term. The top ten terms based on P value were chosen in each category.