Table 1.

Analysis of up-regulated genes in HCV-infected hepatocytes from humanized chimeric mouse

Microarray analysis is described under “Experimental procedures.” The left column shows that cRNA targets from HCV-infected and uninfected humanized mouse livers were conjugated with cyanine 3 (Cy3) and cyanine 5 (Cy5), respectively. The right column shows that, contrary to the left column, Cy5 and Cy3 conjugation were used for cRNA targets from HCV-infected and uninfected humanized livers, respectively. The top five most induced genes are shown.

HCV(+)RNA: Cy3, HCV(−)RNA: Cy5				HCV(+)RNA:Cy5, HCV(−)RNA: Cy3
Gene name	Systematic name	Description	-Fold change	Gene name	Systematic name	Description	-Fold change
EDN2	NM_001956	Homo sapiens endothelin 2 (EDN2)	19.5	CXCL9	NM_002416	H. sapiens chemokine (CXC motif) ligand 9 (CXCL9)	10.7
RRM2	NM_001034	H. sapiens ribonucleotide reductase M2 polypeptide (RRM2)	14.9	RRM2	NM_001034	H. sapiens ribonucleotide reductase M2 polypeptide (RRM2)	10.0
AF231918	AF231918	H. sapiens medium-chain 2-hydroxy acid oxidase HAOX3 (HAOX3) mRNA	14.0	H19	NR_002196	H. sapiens H19, imprinted maternally expressed untranslated mRNA (H19) on chromosome 11 (NR_002196)	9.8
ID4	NM_001546	H. sapiens inhibitor of DNA binding 4, dominant negative helix-loop-helix protein (ID4)	10.8	HLA-DQB1	NM_002123	H. sapiens major histocompatibility complex, class II, DQ β1 (HLA-DQB1	9.1
ARMCX2	NM_014782	H. sapiens armadillo repeat containing, X-linked 2 (ARMCX2)	8.6	HLA-DPB1	NM_002121	H. sapiens major histocompatibility complex, class II, DP β1 (HLA-DPB1)	8.7