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Alignment of amino acid sequences corresponding to the M5-M6 region of flippases and ion pumps. The identification of the transmembrane helices M5 and M6 of ATP8A2 (residues in cyan boxes) is based on the crystal structure of Ca2+-ATPase (14). Lys-873 (K873) and Asn-905 (N905) of the bovine ATP8A2 studied here are indicated. For the ion pumps, residues involved in ion binding are shown in gray boxes.
