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GADD34 and TRAF6 mediate the up-regulation of MCL-1 by TRAIL. A, HepG2 and SMMC-7721 cells were transfected with siControl or siGADD34, followed by treatment with 100 ng/ml of TRAIL for 24 h, and Western blotting analysis of MCL-1 and GADD34. B, HepG2 and SMMC-7721 cells were transfected with siControl or siTRAF6, followed by treatment with or without 100 ng/ml of TRAIL for 24 h and Western blotting analysis of MCL-1, p-ERK1/2 (Thr202/Tyr204), ERK1/2, and TRAF6.
