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Overexpression of MCL-1 rescues TRAIL-treated and GADD34-depleted SMMC-7721 cells from apoptosis. A, SMMC-7721 cells were transfected with siControl or siGADD34 and the MCL-1 expression plasmid or vector followed by treatment with or without 100 ng/ml of TRAIL for 24 h. Cell apoptosis was detected by TUNEL assays. B, the apoptotic rate was plotted. The values represent the means ± S.D. (n = 3). ***, p < 0.001. DAPI, 4′,6′-diamino-2-phenylindole.
