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Transcription activation assays for BRCA1 missense VUS normalized by internal vector and protein levels. A–E, transcription activity of missense variants located at the transition between the disordered region and the BRCT domain normalized against vector control and protein levels (Fig. S1). For comparison, squares denote whether the variant displayed activity similar to WT (open squares) or reduced (<80% WT; filled squares) activity when normalizing against vector control only.
