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A, the sequences of the WT Pu39 region and the truncated mutants Bcl2-2345, Bcl2-1245, and Bcl2-1234. The six G-tracts with three or more guanines are underlined and numbered using Roman numerals. B, schematic structures of Bcl2-2345 and Bcl2-1245 G4s according to previous NMR studies (9, 10). The 13-nt middle loop of the Bcl2-1245 G4 is shown in blue. C, CD spectra of the Pu39, Bcl2-1245, and Bcl2-2345 sequence measured in 100 mm KCl at room temperature.
