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. 2019 Feb 4;294(15):6172–6187. doi: 10.1074/jbc.RA118.006281

Figure 9.

Figure 9.

YY1 expression is negatively correlated with miR-141 and poor prognosis in NPC patients. A, representative images of YY1 expression in noncancerous nasopharyngeal tissues and different clinical TNM stages of NPC detected by IHC. B, box diagram of YY1 expression in noncancerous control (n = 29) and NPC tissues (n = 126). C and E, Kaplan-Meier overall survival analysis of NPC patients by expression of YY1 (C) or both of YY1 and miR-141 (E). Clinicopathological characteristics and statistical significance were assessed using the log-rank test. Kaplan-Meier curves show that worse survival rates in 64 NPC patients with low YY1 protein expression and high miR-141 expression compared with the related controls. D, YY1 and miR-141 expression in NPC. F, working model showing the mechanism of YY1 in negatively regulating cell proliferation and tumor growth in NPC through the inactivation of the c-Myc/miR-141/PTEN/AKT pathway. Error bars represent the mean ± S.D. *, p < 0.05; ***, p < 0.001.