Table 1.

Meta-analysis results of 23 HLA alleles that associated with BMI in CMDP

Allele	Gene	Frequency	P value	β ± SE	Explained variance (%)
A*02	HLA-A	0.306	4.07E-04	0.015 ± 0.004	0.010
B*07	HLA-B	0.030	6.89E-10	0.071 ± 0.011	0.029
B*08	HLA-B	0.009	1.53E-04	0.079 ± 0.021	0.011
B*13	HLA-B	0.110	4.37E-04	0.022 ± 0.006	0.009
B*46	HLA-B	0.100	1.10E-06	0.042 ± 0.009	0.032
B*58	HLA-B	0.057	3.75E-05	0.086 ± 0.021	0.080
C*07	HLA-C	0.176	5.09E-04	0.038 ± 0.011	0.042
DRB1*03	HLA-DRB1	0.048	1.06E-07	0.048 ± 0.009	0.021
DRB1*04	HLA-DRB1	0.113	6.15E-06	0.028 ± 0.006	0.016
DRB1*07	HLA-DRB1	0.093	1.32E-08	0.041 ± 0.007	0.028
DRB1*09	HLA-DRB1	0.145	9.76E-05	0.024 ± 0.006	0.014
DRB1*12	HLA-DRB1	0.121	1.52E-09	0.047 ± 0.008	0.047
A*02:01	HLA-A	0.125	3.75E-06	0.035 ± 0.007	0.027
B*07:02	HLA-B	0.022	1.12E-07	0.089 ± 0.017	0.034
B*27:04	HLA-B	0.010	4.15E-05	0.113 ± 0.028	0.025
B*40:01	HLA-B	0.099	5.78E-05	0.038 ± 0.009	0.026
C*01:03	HLA-C	0.006	1.00E-04	0.182 ± 0.047	0.042
C*03:02	HLA-C	0.059	4.45E-08	0.085 ± 0.016	0.081
DQB1*03:02	HLA-DQB1	0.057	1.94E-04	0.066 ± 0.018	0.047
DQB1*06:02	HLA-DQB1	0.076	9.55E-06	0.122 ± 0.028	0.210
DRB1*03:01	HLA-DRB1	0.048	1.11E-05	0.049 ± 0.011	0.022
DRB1*07:01	HLA-DRB1	0.093	6.49E-06	0.040 ± 0.009	0.027
DRB1*12:02	HLA-DRB1	0.082	5.13E-05	0.047 ± 0.012	0.033

Bold font indicates the HLA alleles with the strongest associations (P < 5.0 × 10⁻⁸). Significance is defined as P ≤ 0.0006 (0.05/72) for low-resolution alleles and P ≤ 0.0003 (0.05/163) for high-resolution HLA alleles based on a stringent Bonferroni correction. Explained variance (%) was estimated based on the effect sizes (β) and allele frequencies in CMDP. β ± SE is the regression slope and its SE.