Table 2.
Lineage | Role | Cell type | Species | FcγRI | FcγRIIa | FcγRIIb | FcγRIIc | FcγRIIIa | FcγRIIIb |
---|---|---|---|---|---|---|---|---|---|
Myeloid | Granulocytes | Neutrophils | H. sapiens | I | + | +/– | + | – | + |
M. fascicularis | ND | ◦ | ◦ | – | – | – | |||
Eosinophils | H. sapiens | ND | + | – | ND | – | + | ||
M. fascicularis | ND | ◦ | ◦ | – | – | – | |||
Basophils | H. sapiens | – | + | + | ND | – | + | ||
M. fascicularis | ND | ◦ | ◦ | – | – | – | |||
Mast Cells | H. sapiens | I | + | – | +/– | – | + | ||
M. fascicularis | ND | ◦ | ◦ | – | – | – | |||
Phagocytes | Monocytes/Macrophages | H. sapiens | I | + | +/– | – | + | – | |
M. mulatta | + | ◦ | ◦ | – | + | – | |||
Dendritic Cells | H. sapiens | + | + | + | – | – | – | ||
M. mulatta | + | ◦ | ◦ | – | – | – | |||
Platelets | H. sapiens | ND | + | – | – | ND | ND | ||
M. mulatta | ND | ND | ND | – | ND | – | |||
Lymphoid | B Cells | H. sapiens | – | – | + | + | – | – | |
M. mulatta | – | ◦ | ◦ | – | – | – | |||
T Cells | H. sapiens | – | – | +/–1 | – | +/–2 | – | ||
M. mulatta | – | ◦ | ◦ | – | – | – | |||
Natural Killer Cells | H. sapiens | – | – | – | + | + | – | ||
M. mulatta | – | ◦ | ◦ | – | + | – |
Positive for FcγR2 but a/b not determined.
Inducible by interferon γ.
Not determined.
Expressed by a low percentage of cells, or by a specific subset.
Subset-specific expression is:
FcγRIIb has been observed on human memory CD8+ T cells (121).
FcγRIIIa has been observed on activated human CD4+ T cells (122).