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. 2016 Feb 18;2016(2):CD007874. doi: 10.1002/14651858.CD007874.pub2

Kim 2014a.

Methods Double‐bind, randomized controlled trial
Participants Age 20 years to 60 years, ASA I‐II, elective surgery
Exclusion criteria: participants with a history of neurological problems or allergies and those who had taken medications
 including sedatives and analgesics within 24 hours of surgery, participants with a body weight of < 55 kg
Recruitment: 69 participants were randomly assigned (68 participants were analysed)
Setting: Korea
Interventions Pretreatment with venous occlusion
Group L40: 40 mg lidocaine (n = 22)
Group L60: 60 mg lidocaine (n = 23)
Group L80: 80 mg lidocaine (n = 23)
The tourniquet was released after 1 min and microemulsion propofol was administered through the same venous cannula to achieve a target effect‐site concentration of 5.2 mg/ml at a maximum flow rate of 750 ml/h, which represented a bolus of 120 mg over 60 sec for a 66 kg participant (the mean weight of the study participants) approximating to an infusion rate of 2 mg/kg per min.
A placebo group was not included for ethical reasons.
To preserve blinding, normal saline (0.9%) was added to give a total volume of study medication of 4 ml in groups L40 and L60.
Outcomes Pain intensity assessed on 4‐point scale
0 = no pain
1 = mild pain
2 = moderate pain
3 = severe pain
Other outcomes: pain incidence, adverse effects
Notes There was no control group