Parhampour 2014.

Methods	Randomized controlled study.
Participants	Inclusion criteria: severe haemophilia A, BMI 22 ‐ 29, no inhibitor, t‐score < 2.5, willingness to comply with the design, regular patient at clinic. Age 20 ‐ 35 years. Exclusion criteria: target joint preventing resistance training, hepatitis B or C, thyroid disorder, steroids, regular physical training more than 2x per week in preceding 6 months, hormone therapy, drugs that influence bone metabolism, hypertension, other orthopedic that might limit ability to participate in resistance training. 70 enrolled in study; 22 excluded based on inclusion criteria; 48 remaining and were randomly assigned to 4 groups. 1. RT only: 13 participants. 2. RT with PEMF: 12 participants. 3. PEMF only: 11 participants. 4. Control no resistance and no PEMF: 12 participants. Within random allocation participants with low t‐scores were evenly distributed within the groups. Duration of study: 6 weeks.
Interventions	Resistance training involved 18 sessions over 6 weeks, 3 times a week, 30 ‐ 40 min, resistance was set based on 1 repetition max (started at 50%, increased to 55%, finished at 60%), 10 reps during weeks 1, 3, 5. 15 reps during weeks 2, 4, 6, amount of rest time was specified. RT only: after exercises received 30 min of placebo PEMF, very good description of exercises provided. RT and PEMF group: 5 reps of each exercise in 1, 3, 5 and 10 reps in weeks 2, 4, 6. After the training program participants received 30 min of PEMF, parameters described. PEMF: no exercise training, 6 weeks of PEMF 1 hour per session over 6 weeks. Control group: no intervention.
Outcomes	Body fat percentage. Modified Colorado Scale, Pediatric (ROM, strength, pain, etc). Blood work for bone biomarkers.
Notes	Conclude that pain is improved but unable to find raw data in results.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomization (using computerized blocks) was carried out....".
Allocation concealment (selection bias)	Low risk	Comment: randomization was carried out by an independent person, not involved in the research project.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Quote: "all patients were blinded to the groupings but the investigator for the modified Colorado Questionnaire was not masked to the group assignment.". Comment: extent to which this unblinded assessment may have influenced outcomes is unclear.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Quote: "the investigator for the modified Colorado Questionnaire was not masked to the group assignment.". Comment: extent to which this unblinded assessment may have influenced outcomes is unclear.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Quote: "Five patients did not complete the project.". Comment: 10% overall dropout rate. Not reported how incomplete data were handled.
Selective reporting (reporting bias)	Unclear risk	Insufficient information provided to make judgement of low or high risk.
Other bias	Low risk	No other sources of bias were identified.