Summary of findings 6. Fondaparinux versus mechanical thromboprophylaxis for the prevention of venous thromboembolism.
| Fondaparinux versus mechanical thromboprophylaxis for the prevention of venous thromboembolism | ||||||
| Patient or population: people requiring prevention of venous thromboembolism Settings: hospital and outpatient Intervention: fondaparinux versus mechanical thromboprophylaxis | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Mechanical thromboprophylaxis | Fondaparinux | |||||
| Total VTE Follow‐up: 4 to 8 days | Study population | RR 0.61 (0.22 to 1.67) | 99 (1 study) | ⊕⊕⊝⊝ low1 | ||
| 176 per 1000 | 108 per 1000 (39 to 295) | |||||
| Moderate | ||||||
| 177 per 1000 | 108 per 1000 (39 to 296) | |||||
| Symptomatic VTE Follow‐up: 4 to 8 days | See comment | See comment | Not estimable | 120 (1 study) | ⊕⊕⊝⊝ low1 | No cases of symptomatic VTE recorded |
| Total DVT Follow‐up: 4 to 8 days | Study population | RR 0.63 (0.23 to 1.72) | 100 (1 study) | ⊕⊕⊝⊝ low1 | ||
| 171 per 1000 | 108 per 1000 (39 to 295) | |||||
| Moderate | ||||||
| 171 per 1000 | 108 per 1000 (39 to 294) | |||||
| Proximal DVT Follow‐up: 4 to 8 days | See comment | See comment | Not estimable | 105 (1 study) | ⊕⊕⊝⊝ low1 | No cases of proximal DVT recorded |
| Total PE Follow‐up: 4 to 8 days | See comment | See comment | Not estimable | 120 (1 study) | ⊕⊕⊝⊝ low1 | No cases of PE recorded |
| Major bleeding Follow‐up: 4 to 8 days | See comment | See comment | Not estimable | 120 (1 study) | ⊕⊕⊝⊝ low1 | No cases of major bleeding recorded |
| All causes of death Follow‐up: 4 to 8 days | See comment | See comment | Not estimable | 120 (1 study) | ⊕⊕⊝⊝ low1 | No deaths recorded |
| *The basis for the assumed risk (e.g. median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; DVT: deep vein thrombosis; PE: pulmonary embolism; RR: risk ratio; VTE: venous thromboembolism. | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 One study included in this comparison, small study sample, funded by pharmaceutical company, very short follow‐up ‐ downgraded by two levels.