Source	Search strategy	Hits retrieved 30 January 2015	Hits retrieved 4 February 2016
1. ALOIS (www.medicine.ox.ac.uk/alois)	palliative OR terminal OR hospice OR dying OR "end of life"	16	0
2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1946 to present (OvidSP)	1. exp Dementia/ 2. Delirium/ 3. Wernicke Encephalopathy/ 4. Delirium, Dementia, Amnestic, Cognitive Disorders/ 5. dement*.mp. 6. alzheimer*.mp. 7. (lewy* adj2 bod*).mp. 8. deliri*.mp. 9. (chronic adj2 cerebrovascular).mp. 10. ("organic brain disease" or "organic brain syndrome").mp. 11. ("normal pressure hydrocephalus" and "shunt*").mp. 12. "benign senescent forgetfulness".mp. 13. (cerebr* adj2 deteriorat*).mp. 14. (cerebral* adj2 insufficient*).mp. 15. (pick* adj2 disease).mp. 16. (creutzfeldt or jcd or cjd).mp. 17. huntington*.mp. 18. binswanger*.mp. 19. korsako*.mp. 20. or/1‐19 21. exp Palliative Care/ 22. "Hospice and Palliative Care Nursing"/ 23. Terminal Care/ 24. "end of life".ti,ab. 25. palliative.ti,ab. 26. (dying adj3 (care or comfort or relief or strateg* or plan or intervention or pain)).ti,ab. 27. "symptom control".ti,ab. 28. (bereavement adj2 support).ti,ab. 29. or/21‐28 30. 20 and 29 31. randomized controlled trial.pt. 32. controlled clinical trial.pt. 33. random$.ti,ab. 34. groups.ab. 35. drug therapy.fs. 36. placebo.ab. 37. rct.ti,ab. 38. or/31‐37 39. 30 and 38	494	48
3. Embase 1974 to 1 February 2016 (OvidSP)	1. exp *dementia/ 2. dement*.ti,ab. 3. alzheimer*.ti,ab. 4. (lewy* adj2 bod*).ti,ab. 5. (frontotemporal* or FTD or FTLD).ti,ab. 6. or/1‐5 7. exp palliative nursing/ or exp palliative therapy/ 8. hospice care/ or hospice/ or hospice nursing/ or hospice patient/ 9. terminal care/ 10. death/ or dying/ 11. palliative.ti,ab. 12. hospice*.ti,ab. 13. terminal.ti,ab. 14. "end of life".ti,ab. 15. (dying adj3 (care or comfort or relief or strateg* or plan or intervention or pain)).ti,ab. 16. ("symptom control" and (dying or death)).ti,ab. 17. (bereavement adj2 support).ti,ab. 18. or/7‐17 19. 6 and 18 20. randomized controlled trial/ 21. controlled clinical trial/ 22. (randomly adj3 (divide* or shared or allocat*)).ti,ab. 23. placebo.ab. 24. "double‐blind*".ti,ab. 25. "single blind*".ti,ab. 26. RCT.ti,ab. 27. (randomized or randomised).ti. 28. or/20‐27 29. 19 and 28	276	37
4. PsycINFO 1806 to January 2016 week 4 (OvidSP)	1. dement*.ti,ab. 2. alzheimer*.ti,ab. 3. exp Dementia/ 4. (lewy* adj2 bod*).ti,ab. 5. (frontotemporal* or FTD or FTLD).ti,ab. 6. or/1‐5 7. exp Hospice/ or exp "Death and Dying"/ or exp Palliative Care/ or exp Terminally Ill Patients/ 8. hospice*.ti,ab. 9. terminal*.ti,ab. 10. "end of life".ti,ab. 11. (dying adj3 (care or comfort or relief or strateg* or plan or intervention or pain)).ti,ab. 12. ("symptom control" and (dying or death)).ti,ab. 13. (bereavement adj2 support).ti,ab. 14. palliative.ti,ab. 15. or/7‐14 16. 6 and 15 17. exp Intervention/ or exp Clinical Trials/ 18. placebo.ab. 19. randomly.ab. 20. (randomised or randomized or RCT or trial).ti,ab. 21. "double‐blind*".ti,ab. 22. "single blind*".ti,ab. 23. or/17‐22 24. 16 and 23	276	15
5. CINAHL (EBSCOhost) 1980 to 31 January 2016	S1 (MH “Dementia”) S2 TX dement* S3 TX alzheimer* S4 TX “lew* bod*” S5 TX FTLD OR FTD OR frontotemporal S6 S1 OR S2 OR S3 OR S4 OR S5 S7 (MH "Palliative Care") OR (MH "Hospice and Palliative Nursing") OR (MH "Terminal Care") OR (MH "Hospice Care”) S8 TX "end of life” S9 TX palliative OR terminal* OR hospice* OR bereavement S10 S7 OR S8 OR S9 S11 S6 AND S10 S12 (MH "Randomized Controlled Trials”) S13 TX randomised S14 TX randomized S15 AB placebo S16 AB randomly S17 AB "double blind*” S18 AB "single blind*” S19 AB RCT S20 S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 S21 S11 AND S20	75	16
6. ISI Web of Science ‐ all databases [includes: Web of Science (1945 to present); BIOSIS Previews (1926 to present); MEDLINE (1950 to present); Journal Citation Reports]	TOPIC: (dement* OR alzheimer* OR "lew* bod*" OR frontotemporal OR FTD OR FTLD OR "severe* cognit* impair*") AND TOPIC: (palliative* OR terminal* OR hospice* OR dying OR "end of life" OR bereavement) AND TOPIC: (RCT OR "randomly alloca*" OR randomised OR randomized OR placebo OR "double blind*" OR "single blind*") Timespan: All years. Search language=Auto	463	37
7. LILACS (BIREME)	demência OR dementia OR demencia OR alzheimer$ [Words] and paliativos OR palliative OR hospice OR terminal OR terminalidade OR morrer OR dying OR morte [Words] and randomizado OR randomised OR randomized OR placebo OR randomly [Words]	1	1
8. CENTRAL (the Cochrane Library) 2016, Issue 1	#1 dement* #2 alzheimer* #3 MeSH descriptor: [Dementia] explode all trees #4 "lew* bod*" or DLB or LBD #5 frontotemporal* or FTD or FTLD #6 #1 or #2 or #3 or #4 or #5 #7 palliative #8 terminal* #9 hospice* #10 "end of life" #11 dying #12 bereavement #13 MeSH descriptor: [Palliative Care] explode all trees #14 MeSH descriptor: [Hospice and Palliative Care Nursing] explode all trees #15 MeSH descriptor: [Terminal Care] explode all trees #16 MeSH descriptor: [Palliative Medicine] explode all trees #17 #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 #18 #17 and #6	131	25
9. Clinicaltrials.gov (www.clinicaltrials.gov)	[condition] dementia OR alzheimer OR alzheimers AND [search terms] palliative OR terminal OR hospice OR dying OR "end of life” Study type: interventional Dates: ALL	66	8
10. ICTRP Search Portal (apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry ‐ India; Clinical Research Information Service ‐ Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register]	[condition] dementia OR alzheimer OR alzheimers AND [intervention] palliative OR terminal OR hospice OR dying OR "end of life” Recruitment status: ALL Dates: ALL	6	0
TOTAL before de‐duplication		1648	187
TOTAL after de‐duplication		1382	157