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. 2016 Dec 8;2016(12):CD005305. doi: 10.1002/14651858.CD005305.pub4

Borges 2014.

Methods Randomised parallel‐group trial
Participants 29 participants with COPD (CG: n = 14, mean age 68 years, 71% males, mean FEV1 39% predicted; IG: n = 15, mean age 64 years, 53% male, mean FEV1 42% predicted) admitted to the hospital for treatment of COPD exacerbation
Interventions Rehabilitation: exercise training started on third day of hospitalisation, inpatient pulmonary rehabilitation (completed 5.6 sessions on average) with whole‐body resistance training for upper and lower limbs (session every morning with free weights in 2 sets of 8 repetitions). Completion rate of pulmonary rehabilitation: 95%. Follow‐up: 1 month
Usual care: Participants received normative daily care, including chest physiotherapy, non‐invasive ventilation if needed and verbal instructions to carry on with their normative daily physical activities. Participants did not receive an exercise programme or a recommendation to exercise after hospital discharge. Follow‐up: 1 month
Outcomes SGRQ, 6MWD
Notes Pulmonary rehabilitation programme was considered not extensive (downgraded by ‐2 for < 10 exercise training sessions and by ‐1 for strength training only).
Financial support was provided by the Sao Paulo Research Foundation (Grant no. 2007/51‐354‐7) and the Brazilian Scientific Foundation (Grant no. 305987/2010‐0).
Clinical trial identifier: NCT01786928
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation
Allocation concealment (selection bias) Low risk "Allocation was concealed in sequentially numbered, sealed, opaque envelopes"
Blinding (performance bias and detection bias) 
 Hospital admission Unclear risk Information not available from trial report
Blinding (performance bias and detection bias) 
 Health‐related quality of life High risk Information not available from trial report. Although unavoidable by definition, lack of blinding may affect outcome.
Blinding (performance bias and detection bias) 
 Mortality Unclear risk Information not available from trial report
Blinding (performance bias and detection bias) 
 Walk test Low risk "Evaluation[s] were performed by a blinded evaluator."
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Losses to follow‐up are detailed for both groups, and the final number of participants is balanced between comparison groups.
Selective reporting (reporting bias) Low risk Outcome reporting is sufficiently complete and transparent. Clinical trial registration number is not reported.
Other bias Low risk No indication of other biases