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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Angiogenesis. 2018 Jun 28;21(4):837–848. doi: 10.1007/s10456-018-9628-3

Figure 2: Heparin impaired compensatory lung growth, plethysmographic measurements, and activity levels in mice after left pneumonectomy.

Figure 2:

Systemically heparinized mice had higher plasma heparin activity levels compared to control mice as assessed by anti-factor IIa activity assays (A). The heparin group displayed the lowest lung volume among the 4 experimental groups on post-operative day (POD) 4. Compared to the control group, the heparin group demonstrated lower plethysmographic parameters, including expiratory volume (C), tidal volume (D), minute ventilation (E), peak inspiratory flow (F), peak expiratory flow (G), and mid-expiratory flow (H). Systemically heparinized mice also demonstrated reduced walking distance (I) and movement counts (J–K) on open field studies. Statistical analyses of lung volume among the experimental groups were performed with ANOVA and Holm-Sidak correction for multiple comparisons. Results are expressed as mean ± SE. *: P ≤ 0.05; **: P ≤ 0.01; ****P ≤ 0.0001.