Heisterberg 2007.

Methods	Allocation: randomised. Blindness: double. Duration: 6 weeks. Setting: no information available. Design: multicentre, parallel groups.
Participants	Diagnosis: schizophrenia as per DSM‐IV‐TR. N = 599. Age: 18‐69 years. Sex: male and female. History: having an acute exacerbation of schizophrenia. Inclusion criteria: baseline PANSS score of 70 to 120 and CGI score of ≥ 4. Exclusion criteria: no information available.
Interventions	1. Risperidone: dose 6 mg/day, N = 154. 2. Placebo: N = 149. 3. Bifeprunox: N = 296.
Outcomes	Adverse events: lipid parameters*, EPS. Leaving the study early. Unable to use: Adverse effects: weight change (no SD reported).
Notes	Study attrition was 60% at the end of 6 weeks ‐‐ no data included in efficacy analysis. *We reported this data as the paper used LOCF to account for missing values.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, no further information. Quote: "...patients with acutely exacerbated schizophrenia were randomly assigned to..."
Allocation concealment (selection bias)	Unclear risk	No information available.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	ITT analysis done.
Selective reporting (reporting bias)	Unclear risk	Outcomes listed in the methods were reported.
Other bias	Low risk	None obvious.