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Proposed model for maspin-CL binding in the IMM and release of cytochrome c into the cytoplasm A) Cytochrome c (Cyt C) is bound to CL (depicted in red) in the IMM. Maspin (Mp) is in the cytosol. B) Apoptosis is induced and maspin translocated from the cytosol into mitochondria. C) Maspin competes with cytochrome c for binding to CL in the IMM, and cytochrome c is released from mitochondria and triggers apoptosis.
