Figure 7.

Decreased synthesis of POA in PHT cells in maternal obesity. Unlabeled POA, newly synthesized U[¹³C]-POA, and the respective POA:PA ratios in total cellular lipid fraction in PHT cells isolated from obese (Ob, gray bars) and normal BMI (C, black bars) mothers at 2 and 30 h of incubation with U[¹³C]-FA mixture. A, B) Unlabeled POA concentration (A) and unlabeled POA:PA ratio (B) at 2 and 30 h in obese mothers vs. those with normal BMI. C) U[¹³C]-POA concentration produced from desaturation of U[¹³C]-PA at 2 and 30 h. D) U[¹³C]-POA:U[¹³C]-PA ratio in obese mothers vs. control group (n = 7 in each group, means + sem). *P < 0.05, **P < 0.01 (Mann-Whitney U test).