TABLE 1.

Proteins identified by proteomics in exosomes and their function

Protein function	Protein
Extracellular matrix	Collagen, fibronectin, vitronectin, heparan sulfate glycans, laminin, glypican-1
Histones	H1, H2A, H3, H4
Heat shock proteins	70, 71, 90, β 1
Histocompatibility antigen class 1	A, B, and C
Annexins	A1, A2, A4, A5, A6, A7
Matrix metalloproteases/inhibitors	MMP1, MMP2, MMP14, ADAM9, ADAM10, ADAM17, TIMP-2, TIMP-3
Integrins	α1, α2, α3, α4, α5, α6, α8, α11, αv, β1, β3, β5
Cytoskeletal proteins	Actin, actinin, tubulin, ephrin
Signaling molecules	HGF, galectin 1, α-catenin, β-catenin, platelet-derived growth factor, TGF-β, Wnt5a, tissue factor

ADAM, a disintegrin and metalloprotease; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase.