TABLE 2.
Pathways identified by STRING pathway database for cellular component, molecular function, biologic process, and KEGG pathways
| Pathway ID | Pathway description | Observed gene count | False discovery rate |
|---|---|---|---|
| Cellular component | |||
| GO.1903561 | EV | 265 | 5.62E−137 |
| GO.0070062 | Extracellular exosome | 264 | 1.41E−136 |
| GO.0044421 | Extracellular region part | 285 | 5.15E−129 |
| GO.0031988 | Membrane-bounded vesicle | 265 | 9.20E−115 |
| GO.0031982 | Vesicle | 267 | 1.20E−113 |
| GO.0005576 | Extracellular region | 289 | 2.49E−113 |
| GO.0005925 | Focal adhesion | 107 | 9.12E−97 |
| GO.0030055 | Cell-substrate junction | 106 | 3.17E−94 |
| GO.0005912 | Adherens junction | 103 | 8.32E−84 |
| GO.0030054 | Cell junction | 110 | 4.06E−49 |
| GO.0005615 | Extracellular space | 98 | 2.55E−33 |
| GO.0044420 | Extracellular matrix component | 36 | 1.66E−31 |
| GO.0031012 | Extracellular matrix | 54 | 1.69E−30 |
| GO.0005829 | Cytosol | 149 | 6.83E−28 |
| GO.0031410 | Cytoplasmic vesicle | 84 | 1.34E−27 |
| GO.0016023 | Cytoplasmic membrane-bounded vesicle | 80 | 2.18E−27 |
| GO.0009986 | Cell surface | 65 | 1.33E−25 |
| GO.0005578 | Proteinaceous extracellular matrix | 46 | 1.37E−24 |
| Molecular function | |||
| GO.0005515 | Protein binding | 220 | 1.95E−48 |
| GO.0005198 | Structural molecule activity | 67 | 7.65E−31 |
| GO.0032403 | Protein complex binding | 65 | 7.65E−31 |
| GO.0044822 | Poly(A) RNA binding | 90 | 1.16E−28 |
| GO.0003723 | RNA binding | 101 | 4.22E−27 |
| GO.0050839 | Cell adhesion molecule (CAM) binding | 33 | 5.05E−25 |
| GO.0044877 | Macromolecular complex binding | 80 | 1.68E−24 |
| GO.0005488 | Binding | 288 | 1.76E−23 |
| GO.0005201 | Extracellular matrix structural constituent | 22 | 2.23E−19 |
| GO.0005102 | Receptor binding | 69 | 7.40E−17 |
| GO.0005178 | Integrin binding | 21 | 1.53E−16 |
| GO.0019838 | Growth factor binding | 22 | 3.14E−16 |
| GO.0097367 | Carbohydrate derivative binding | 100 | 3.27E−15 |
| GO.0019899 | Enzyme binding | 70 | 2.95E−13 |
| GO.0005518 | Collagen binding | 15 | 4.22E−13 |
| GO.0048407 | Platelet-derived growth factor binding | 9 | 4.99E−12 |
| GO.0042802 | Identical protein binding | 52 | 5.96E−10 |
| GO.1901363 | Heterocyclic compound binding | 160 | 3.21E−09 |
| GO.0043168 | Anion binding | 97 | 3.41E−09 |
| Biologic process | |||
| GO.0030198 | Extracellular matrix organization | 74 | 3.79E−52 |
| GO.0022411 | Cellular component disassembly | 77 | 3.63E−44 |
| GO.0071822 | Protein complex subunit organization | 108 | 4.86E−36 |
| GO.0009611 | Response to wounding | 81 | 5.31E−36 |
| GO.0042060 | Wound healing | 77 | 1.67E−35 |
| GO.0016043 | Cellular component organization | 198 | 1.78E−35 |
| GO.0022617 | Extracellular matrix disassembly | 39 | 2.99E−35 |
| GO.0007155 | Cell adhesion | 77 | 2.96E−26 |
| GO.0022008 | Neurogenesis | 92 | 6.81E−26 |
| GO.0007399 | Nervous system development | 108 | 1.77E−24 |
| GO.0007411 | Axon guidance | 49 | 6.32E−24 |
| GO.0061564 | Axon development | 54 | 2.22E−23 |
| GO.0031175 | Neuron projection development | 59 | 5.57E−22 |
| GO.0007409 | Axonogenesis | 51 | 1.04E−21 |
| GO.0048812 | Neuron projection morphogenesis | 53 | 2.82E−21 |
| GO.0048666 | Neuron development | 62 | 4.07E−20 |
| KEGG pathways | |||
| 4510 | Focal adhesion | 52 | 5.60E−41 |
| 4512 | Extracellular matrix receptor interaction | 36 | 3.90E−37 |
| 4151 | PI3K-Akt signaling pathway | 52 | 1.25E−29 |
| 4810 | Regulation of actin cytoskeleton | 31 | 4.99E−17 |
| 4015 | Rap1 signaling pathway | 21 | 9.70E−09 |
| 4520 | Adherens junction | 13 | 1.31E−08 |
| 4540 | Gap junction | 13 | 1.10E−07 |
| 4514 | CAMs | 15 | 8.10E−07 |
| 4530 | Tight junction | 13 | 1.24E−05 |
| 4360 | Axon guidance | 12 | 4.47E−05 |
| 4144 | Endocytosis | 14 | 0.00021 |
| 4390 | Hippo signaling pathway | 11 | 0.00107 |
| 4014 | Ras signaling pathway | 13 | 0.00259 |
| 4010 | MAPK signaling pathway | 14 | 0.00287 |
| 4062 | Chemokine signaling pathway | 9 | 0.0431 |
| 4110 | Cell cycle | 7 | 0.0487 |