Figure 1.

A) Model paradigm and effects of PB on body weight and colonic length. Model of experimental timeline to assess the acute (7 d) and chronic (30 d) effects of a 7-d exposure of PB in mice. B) Model showing the mechanism of action of PB in the ACh pathway. C, E) Body weight of acute and chronic male (C) or female (E) mice of either drinking water or water containing PB. There was no difference in weight between treated and untreated animals. D) Summary data showing decreased colonic length measurements in PB-treated male mice at d 7, but no difference at d 30. F) Females show no difference at d 7 but have decreased colonic length at d 30 (F) (n = 7–8 animals/group). *P < 0.05 compared with control.