Comparison 11. (2.5) Nitric oxide donors versus vaginal prostaglandins (all primiparae, unfavourable cervix).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Uterine hyperstimulation with FHR changes	1	398	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.1 Isosorbide Mononitrate	1	398	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Caesarean section	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.80, 1.43]
2.1 Isosorbide Mononitrate	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.80, 1.43]
3 Epidural analgesia	1	394	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.91, 1.18]
3.1 Isosorbide Mononitrate	1	394	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.91, 1.18]
4 Instrumental vaginal delivery	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.76, 1.37]
4.1 Isosorbide Mononitrate	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.76, 1.37]
5 Apgar score < 7 at 5 minutes	1	394	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.15, 2.50]
5.1 Isosorbide Mononitrate	1	394	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.15, 2.50]
6 Neonatal intensive care unit admission	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.45, 1.93]
6.1 Isosorbide Mononitrate	1	395	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.45, 1.93]
7 Maternal side effects (nausea)	1	385	Risk Ratio (M‐H, Fixed, 95% CI)	1.79 [1.10, 2.93]
7.1 Isosorbide Mononitrate	1	385	Risk Ratio (M‐H, Fixed, 95% CI)	1.79 [1.10, 2.93]
8 Maternal side effects (headache)	1	383	Risk Ratio (M‐H, Fixed, 95% CI)	8.73 [5.68, 13.41]
8.1 Isosorbide Mononitrate	1	383	Risk Ratio (M‐H, Fixed, 95% CI)	8.73 [5.68, 13.41]