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. 2016 Dec 5;2016(12):CD006901. doi: 10.1002/14651858.CD006901.pub3

Comparison 17. (3.5) Nitric oxide donors versus intracervical prostaglandins (all primiparae, unfavourable cervix).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Uterine hyperstimulation with FHR changes 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
1.1 Glyceryl Trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
2 Caesarean section 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.43, 1.55]
2.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.43, 1.55]
3 Serious neonatal morbidity/perinatal death 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
3.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
4 Cervix unfavourable/unchanged after 12‐24 hours 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.29 [0.59, 2.81]
4.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.29 [0.59, 2.81]
5 Oxytocin augmentation 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.89 [0.43, 1.85]
5.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.89 [0.43, 1.85]
6 Uterine hyperstimulation without FHR changes 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.14 [0.01, 2.61]
6.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.14 [0.01, 2.61]
7 Instrumental vaginal delivery 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.07, 14.95]
7.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.07, 14.95]
8 Perinatal death 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
8.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 7.74]
9 Maternal side effects (headache) 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 10.0 [1.40, 71.32]
9.1 Glyceryl trinitrate 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 10.0 [1.40, 71.32]