Skip to main content
. 2016 Dec 5;2016(12):CD006901. doi: 10.1002/14651858.CD006901.pub3

Comparison 19. (4.1) Nitric oxide donors versus vaginal misoprostol (all women).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Vaginal delivery not achieved in 24 hours 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 5.33 [1.62, 17.55]
1.1 Isosorbide mononitrate 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 5.33 [1.62, 17.55]
2 Uterine hyperstimulation with FHR changes 3 281 Risk Ratio (M‐H, Fixed, 95% CI) 0.07 [0.01, 0.37]
2.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 0.22 [0.01, 4.30]
2.2 Isosorbide Mononitrate 2 237 Risk Ratio (M‐H, Fixed, 95% CI) 0.05 [0.01, 0.40]
3 Caesarean section 6 761 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.82, 1.21]
3.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.47, 1.72]
3.2 Isosorbide Mononitrate 4 587 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.84, 1.28]
3.3 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.76 [0.37, 1.55]
4 Serious neonatal morbidity/perinatal death 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Isosorbide Mononitrate 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Cervix unfavourable/unchanged after 12‐24 hours 2 151 Risk Ratio (M‐H, Fixed, 95% CI) 3.43 [2.07, 5.66]
5.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 2.46 [0.89, 6.82]
5.2 Isosorbide Mononitrate 1 107 Risk Ratio (M‐H, Fixed, 95% CI) 3.78 [2.12, 6.75]
6 Oxytocin augmentation 7 767 Risk Ratio (M‐H, Random, 95% CI) 2.67 [1.31, 5.45]
6.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Random, 95% CI) 1.25 [0.55, 2.85]
6.2 Isosorbide Mononitrate 5 593 Risk Ratio (M‐H, Random, 95% CI) 3.57 [1.84, 6.92]
6.3 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Random, 95% CI) 1.30 [1.11, 1.52]
7 Uterine hyperstimulation without FHR changes 3 367 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.01, 0.32]
7.1 Isosorbide Mononitrate 2 237 Risk Ratio (M‐H, Fixed, 95% CI) 0.05 [0.01, 0.34]
7.2 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.01, 3.96]
8 Epidural analgesia 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.45, 1.31]
8.1 Isosorbide Mononitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.45, 1.31]
9 Instrumental vaginal delivery 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.07, 16.43]
9.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.07, 16.43]
9.2 Isosorbide Mononitrate 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 Meconium‐stained liquor 2 260 Risk Ratio (M‐H, Fixed, 95% CI) 0.29 [0.13, 0.65]
10.1 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.09 [0.00, 1.56]
10.2 Isosorbide mononitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.35 [0.15, 0.84]
11 Apgar score < 7 at 5 minutes 6 777 Risk Ratio (M‐H, Fixed, 95% CI) 0.16 [0.07, 0.38]
11.1 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
11.2 Isosorbide Mononitrate 5 647 Risk Ratio (M‐H, Fixed, 95% CI) 0.16 [0.07, 0.38]
12 Neonatal intensive care unit admission 4 587 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.09, 0.43]
12.1 Isosorbide Mononitrate 4 587 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.09, 0.43]
13 Perinatal death 2 194 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
13.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
13.2 Isosorbide Mononitrate 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Maternal side effects (nausea) 5 647 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.63, 2.17]
14.1 Isosorbide Mononitrate 5 647 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.63, 2.17]
15 Maternal side effects (headache) 4 341 Risk Ratio (M‐H, Fixed, 95% CI) 10.98 [4.05, 29.73]
15.1 Glyceryl Trinitrate 1 44 Risk Ratio (M‐H, Fixed, 95% CI) 5.48 [1.35, 22.17]
15.2 Isosorbide Mononitrate 2 167 Risk Ratio (M‐H, Fixed, 95% CI) 13.46 [2.69, 67.43]
15.3 Isosorbide Dinitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 24.25 [1.47, 401.26]
16 Postpartum haemorrhage 4 587 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.57, 3.06]
16.1 Isosorbide Mononitrate 4 587 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.57, 3.06]
17 Analgesia requirement 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.26 [0.13, 0.49]
17.1 Isosorbide Mononitrate 1 130 Risk Ratio (M‐H, Fixed, 95% CI) 0.26 [0.13, 0.49]
18 Additional induction agents required 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 16.67 [5.44, 51.09]
18.1 Isosorbide mononitrate 1 150 Risk Ratio (M‐H, Fixed, 95% CI) 16.67 [5.44, 51.09]