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. 2016 Dec 15;2016(12):CD002830. doi: 10.1002/14651858.CD002830.pub3

Comparison 1. Droperidol versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Tranquillisation or asleep: 1. tranquillised/sleep 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 By 5 minutes 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.32 [0.90, 1.96]
1.2 By 10 minutes 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.36 [1.08, 1.71]
1.3 By 30 minutes 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.18 [1.05, 1.31]
1.4 By 60 minutes 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [1.00, 1.18]
2 Tranquillisation or asleep: 2. difficulty in achieving tranquillisation/sleep 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 0.51 [0.10, 2.75]
3 Tranquillisation or asleep: 3. time to tranquillisation/sleep (minutes) 1 227 Mean Difference (IV, Fixed, 95% CI) ‐46.5 [‐86.83, ‐6.17]
4 Global state: use of additional medication 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 "To reach initial adequate sedation" 1 227 Risk Ratio (M‐H, Random, 95% CI) 0.50 [0.28, 0.89]
4.2 By 3 minutes (haloperidol) 1 41 Risk Ratio (M‐H, Random, 95% CI) 0.37 [0.18, 0.72]
4.3 By 30 minutes (any psychotropic drug) 1 41 Risk Ratio (M‐H, Random, 95% CI) 0.46 [0.17, 1.24]
4.4 By 60 minutes (midazolam, droperidol, olanzapine, haloperidol) 1 227 Risk Ratio (M‐H, Random, 95% CI) 0.64 [0.42, 0.96]
4.5 By 60 minutes after initial adequate sedation until emergency department discharge (various psychotropic drugs) 1 227 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.36, 0.85]
5 Adverse effects 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Cardiovascular ‐ arrhythmia 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.01, 8.31]
5.2 Cardiovascular ‐ hypotension 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 0.68 [0.20, 2.36]
5.3 Central nervous system ‐ oversedation (decreased Glasgow Coma Score of 6) 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.01, 8.31]
5.4 Respiratory ‐ airway obstruction 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 0.62 [0.15, 2.52]
5.5 Respiratory ‐ oxygen desaturation 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.42, 2.49]
5.6 Unspecified ‐ by 3 minutes 1 41 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Service use: 1 person able to be discharged home 1 227 Risk Ratio (M‐H, Fixed, 95% CI) 1.16 [0.90, 1.48]
7 Service use: 2 emergency department length of stay     Other data No numeric data